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Thyroid-stimulating hormone measurement
Measurement of thyroid-stimulating hormone from blood serum is regarded as the most important test for early detection of hyperthyroidism and hypothyroidism, and is one step of the process used by health care providers to accurately diagnose and treat thyroid disease.〔
〕 The result of this assay is suggestive of the presence and cause of thyroid disease, since a measurement of elevated TSH generally indicates hypothyroidism, while a measurement of low TSH generally indicates hyperthyroidism.〔(Military Obstetrics & Gynecology > Thyroid Function Tests ) In turn citing: Operational Medicine 2001, Health Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington, D.C., 20372-5300〕 However, when TSH is measured by itself, it can yield misleading results, so additional thyroid function tests must be compared with the result of this test for accurate diagnosis.〔
== History ==
First-generation TSH assays were done by radioimmunoassay and were introduced in 1965.〔 There were variations and improvements upon TSH radioimmunoassay, but their use declined as a new immunometric assay technique became available in the middle of the 1980s.〔〔 The new techniques were more accurate, leading to the second, third, and even fourth generations of TSH assay, with each generation possessing ten times greater functional sensitivity than the last. Third generation immunometric assay methods are typically automated.〔 Fourth generation TSH immunometric assay has been developed for use in research.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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